Granulocyte macrophage colony - stimulating factor and the 3 intestinal innate immune cell homeostasis in Crohn ' s disease
نویسنده
چکیده
7 8 9 Running title GM-CSF and the intestinal immune homeostasis 10 11 Institutions The Royal Children’s Hospital Melbourne, Murdoch Children’s Research 12 Institute, Gastrointestinal Research in Inflammation & Pathology, Parkville 13 3052, VIC, Australia 14 University of Melbourne, Melbourne Medical School, Department of 15 Paediatrics, Parkville 3052, VIC, Australia 16 University Children’s Hospital Münster, Department of Pediatric 17 Rheumatology and Immunology, Röntgenstr. 21, Münster 48149, NRW, 18 Germany 19 University of Münster, Interdisciplinary Center for Clinical Research 20 (IZKF), Münster 48149, NRW, Germany 21 22 Correspondence Dr. Jan Däbritz, MD 23 Royal Children’s Hospital Melbourne 24 Murdoch Children’s Research Institute 25 Gastrointestinal Research in Inflammation & Pathology (GRIP) 26 Parkville VIC 3052, Australia 27 Tel: +61 3 9936 6044; Fax: +61 3 9936 6528 28 E-Mail: [email protected] 29 30 Articles in PresS. Am J Physiol Gastrointest Liver Physiol (February 6, 2014). doi:10.1152/ajpgi.00409.2013
منابع مشابه
Granulocyte macrophage colony-stimulating factor and the intestinal innate immune cell homeostasis in Crohn's disease.
Current literature consolidates the view of Crohn's disease (CD) as a form of immunodeficiency highlighting dysregulation of intestinal innate immunity in the pathogenesis of CD. Intestinal macrophages derived from blood monocytes play a key role in sustaining the innate immune homeostasis in the intestine, suggesting that the monocyte/macrophage compartment might be an attractive therapeutic t...
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